Indian Journal of Obstetrics and Gynecology Research

Print ISSN: 2394-2746

Online ISSN: 2394-2754


Indian Journal of Obstetrics and Gynecology Research (IJOGR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific more...

  • Article highlights
  • Article tables
  • Article images

Article statistics

Viewed: 90

PDF Downloaded: 91

Mishra, Sinha, Panda, Priya A, and Rath: A retrospective study of ruptured tubal ectopic pregnancy managed by open and minimal invasive surgery


Ectopic pregnancy is one of the most emergency condition during the pregnancy period,1 in which the fertilized egg implanted outside the uterine cavity. The occurrence of ectopic pregnancy accounts for approximately 2% of total pregnancy in worldwide, whereas in India the incidence is 3.5 to 7.1% and is a major cause of maternal morbidity and mortality with pregnancy loss.2 Most of the ectopic pregnancies are fallopian tube pregnancy and generally, the diagnosis happens after seven weeks of amenorrhoea with or without symptoms.3, 4 Tubal rupture is sudden and life threatening emergency, which needs immediate attention.

Laparoscopy and Laparotomy both are established in gynaecology for several years.5 Since early 1990s, minimally invasive surgery is considered to be the safest and effective surgical technique. In the developed countries laparoscopy is widely used for management of ruptured ectopic pregnancy because of the availability of skilled manpower, logistics, improved anaesthesia and cardiovascular monitoring, well organised surgical care and good healthcare insurance. For ruptured tubal ectopic pregnancy management, Laparoscopic procedures implemented with an aim to reduce intra operative blood loss, analgesic requirements, hospital stay and higher recovery as well as it’s effectiveness in patients with massive haemoperitonium.6, 7 However, Laparotomy is still preferred surgery in low resource set ups.

Materials and Methods

A clinical retrospective study on ruptured tubal ectopic pregnancy was conducted at Pradyumna Bal Memorial hospital, Kalinga Institute of medical science(KIMS), Bhubaneswar, Odisha during the period of three years. A total of 90 cases with ruptured tubal ectopic pregnancy were admitted in an emergency condition and had undergone operative management. Out of them 68 cases were managed with laparoscopic method and 22 patients were managed with laparotomy procedure. The condition of ruptured tubal ectopic pregnancy was characterised based on age, gravida, parity, previous spontaneous loss, previous MTP, Hb at admission, period of gestation, total blood loss and haemoperitonium. Physical and transvaginal diagnosis were carried over on the basis of location of rupture, abdomen condition and blood loss. The selection of surgery method was not based on any specific criteria but dependent on the affordability and choice of patient. Post-operative parameters assessed here are Hb after surgery, blood transfusion and duration of hospital stay. Clinically and surgically acquired data were analysed by statistical analysis with the help of STATA software to generate mean, standard deviation, correlation coefficient, hypothesis test by Chi square and p value for significance and non-significance between different parameters P-value less than 0.05 was considered to be significant.


During three years of study period, 90 ruptured tubal ectopic pregnancy patients presented at the hospital in an emergency condition. Patients were managed by both open surgery (Laparotomy) and minimal invasive Laparoscopic surgery on the basis of availability of facilities and logistics as well as skilled manpower. Characteristics of patients with ruptured tubal ectopic pregnancy were reported and statistically analysed. On the basis of Patient’s history, clinical symptoms, physical examination and transvaginal sonography, patients were grouped into two and were managed with laparoscopy and laparotomy. A comparative demographic profile of clinical data of two groups are shown in Table 1. There was no significant difference between both the groupsin age, gravida, parity, previous history of spontaneous loss, previous MTP. Most of the patients were in 30 to 32 age group with 2-3 gravida and 1 parity. Previous history of spontaneous loss was observed in 13 - 22% patients in laparotomy and laparoscopic group respectively. Previous history of abortion was found in 16 - 18% of patients. Maximum number of patients of laparoscopic group were admitted in 6-10 weeks of gestational period and 45% patients were admitted with blood loss around 1000ml, which were preferably managed with laparoscopic surgery and were having massive hemoperitonium at presentation.

All operative outcome is summarized in Table 2 and all were presented with ruptured tubal ectopic pregnancy. Most of the ruptured cases were from ampulla region (55%) and from corneal 11%, Fimbrial 12%, interstitial 21%. The incidence of cornual rupture was more whereas, the incidence of ectopic rupture in interstitial location was less than other locations. The blood loss was based on the location of rupture. More than 1000 ml blood loss was observed in cornual and Interstitial location in 80% and 26% patients respectively, whereas in ampulla location it was observed in 12% patients. The ruptured tubal ectopic pregnancy cases had taken for laparoscopic and laparotomy surgery based on the availability of skilled person, OT facilities and patient’s willingness. Infusion of red blood cell (3 PRBC) was more in patients having ectopic ruptureat interstitial location (26%) whereas in ampulla and Cornual location the requirement of PRBC was observed in 4% patients. (Table 3) Hospital stay was also more in tubal rupture at ampulla and interstitial location. In case of laparoscopic group the FFP blood transfusion was less than laparotomy procedure. And hospital stay was also reduced to 4 days than laparotomy (7 days).

Table 1

Characteristics of ruptured ectopic pregnancy managed with both


Laparoscopy (n=68)

Laparotomy (n=22)

Age (median) in years



Gravida (median)



Parity (median)




Spontaneous loss (%)



Previous MTP (%)



Hb at admission

7 mg



Acute abdomen (%)



Incidental (%)



Period of gestation (%)

< 6 weeks: 35

< 6 weeks: 27

6-10 weeks: 55

6-10 weeks: 68

> 6 weeks : 8

> 6 weeks : 4.5

Total blood loss (%)

<500 mL: 34

<500 mL: 36

500-1000mL: 44

500-1000ml: 36

>1000mL : 22

>1000mL : 27




Table 2

Distribution of patients on the basis of location and post-operative recovery





Ampulla: 54.4%

Ampulla: 59%

Cornual: 10%

Cornual: 13.6%

Fimbrial: 13%

Fimbrial: 9%

Interstitial: 22%

Interstitial: 18%

No of PRBC transfusions (%)



Duration of hospital stay (days)



[i] Laparoscopyand laparotomy method

Table 3

Location wise tubal ruptured ectopic pregnancy intotal 90 patients

Location of Sac

Blood loss >1000ml (%)

3 PRBC (%)

Hospital stay (7 days) (%)


















Tubal ectopic pregnancy is a major Life risk complication during pregnancy period. Excision of tubal ectopic pregnancy by laparoscopic approach was done for the first time by Shapiro & Adler.8 Advancement in the field of minimal access surgery has increased the scope of laparoscopic management. Laparoscopic approach for management of ectopic pregnancy has largely replaced laparotomy.9 In the present study ruptured tubal ectopic pregnancy was managed with laparoscopic approach in 75.5% cases. All the ruptured tubal ectopic pregnancy cases (90) were taken for emergency operative procedures either laparoscopy or laparotomy. Age, gravida, parity, previous history of spontaneous loss and previous MTP were having no significance in selection of laparoscopic and laparotomy procedure. In the laparoscopic group, haemoperitonium with estimated with blood loss more than 1000ml was observed in 68% patients and were successfully operated with laparoscopic procedure. Laparoscopic procedure is not only safe for early ectopic pregnancy but also appropriate for tubal rupture with haemoperitonium. (tubal ectopic pregnancy LS Vs LT). The most common symptom like acute abdomen was observed in 80% cases of laparoscopic group. Laparoscopic surgery was successfully conducted in 22% cases of patients with more than 1000 ml blood loss at the presentation. Similar results were reported by other authors.7 In the present study, laparoscopic procedure was applied successfully in tubal ectopic pregnancy of different location. An ampullary pregnancy was managed in a better way through laparoscopic procedure than other locations. Cornual pregnancies mostly operated with laparotomy and surgical excision. Whereas, in the present study. 10% corneal localized ectopic pregnancies were managed with laparoscopy and 13.6% were managed with laparotomy.10, 11 Hospital stay was 4 days in case of laparoscopic procedures, whereas in case of laparotomy it was 7 days. Shorter hospital stay can help patients for faster recovery, decreased need of analgesic and better quality of life.12, 13, 14, 15, 16


In our study, laparoscopy is found to be advantageous over laparotomy in terms of shorter hospital stay and speedy recovery. Even, massive haemoperitoneum is not a contraindication for minimal invasive surgery.

Generalised availability of logistics and skilled team will make laparosopic surgery cost effective. This will have positive impact on outcomes of ruptured ectopic pregnancies in periphery and low cost set ups.

Source of Funding


Conflict of Interest

The author declares no conflict of interest.



H Murray H Baakdah T Bardell T Tulandi Diagnosis and treatment of ectopic pregnancyCMAJ200511890512


S Tahmina M Daniel P Solomon Clinical analysis of ectopic pregnancies in tertiary care centre in sourthen India: A six year retrospective studyJ Clin Diagn Res20161010136


JI Tay J Moore JJ Walker Ectopic pregnancyBMJ200032072399169


J Bouyer J Coste H Fernandez JL Pouly N Jobs-Sipra Sites of ectopic pregnancy: a 10year population- based study of 1800 casesHum Reprod200217322430


A Darzy S Mackay Clinical review: Recent advances in minimal access surgeryBMJ2002324331


NS Quareshi JO Wiener A Weerakkody Laparoscic management of tubal pregnancy: availability of trainingObstet Gynaecol200682515


RE Leach SJ Ory Modern management of ectopic pregnancyJ Reprod Med19893432438


HL Shapiro DH Adler Excision of an ectopic pregnancy through the laparoscopeAm J Obstet Gynaecol1973117290


C Vasile P Litta G Sacco M Minante Laparoscopic surgical approach to ectopic pregnancyClin Exp Obstet Gynecol1999261358


T Tulandi M Guralnick Treatment of tubal ectopic pregnancy by salpingotomy with or without tubal suturing and salpingectomyFertil Steril199153535


H Reich F McGlynn R Brudin G Tsontsoplides D Carprio Laparoscopic treatment of ruptured interstitial pregnancyJ Gynaecol Surg199061358


M Vermesh PD Silva GF Rosen AL Stein GT Fossum Sauer Management of unruptured ectopic gestation by linear salpingostomy: a prospective, randomized clinical trial of laparoscopy versus laparotomyObstet Gynecol1989734004


MN Ei-Tabbakh MS Elsays Tubal ectopic pregnancy: Laparoscopy Vs LaparotomyContemporary OB/GYN2011


XD Xiang YQ Tane JFA Mao Comparison of laparoscopic surgery and laparotomy in the treatment of ectopic pregnancySingapore Med. J19994028890


DT Gray J Thorburn P Lundrof A cost effective study of a randomized trial of laparoscopy versus laparotomyLancet19953458958113943


AA Murphy CW Nager JJ Wujek LM Kettel VA Torp HG Chin Operative laparoscopy versus laparotomy for the management of ctopic pregnancy: A prospective trialFertil Steril199257611805


© This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Article type

Original Article

Article page


Authors Details

Abhipsa Mishra, Mohini Sinha, Bandita Panda, Sri Lakshmi Priya A, Sudhanshu Kumar Rath*

Article History

Received : 24-04-2021

Accepted : 24-05-2021

Available online : 25-08-2021

Article Metrics

View Article As


Downlaod Files


Wiki in hindi