Indian Journal of Obstetrics and Gynecology Research

Print ISSN: 2394-2746

Online ISSN: 2394-2754


Indian Journal of Obstetrics and Gynecology Research (IJOGR) an open access, peer-reviewed quarterly journal publishing since 2014 and being published under auspices of the Innovative Education and Scientific Research Foundation (IESRF). The aim of faster and better dissemination of knowledge, we will be publishing article ‘Ahead of Print’ immediately on acceptance. In addition, the journal would allow free access (Open Access) to its contents, which is likely to attract more readers and citations more...

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M V Ramana Rao, Naima Fathima*, Monica G

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A comparative study of single versus multiple instillations of intravaginal PGE2 gel for induction of labour

Original Article

Author Details : M V Ramana Rao, Naima Fathima*, Monica G

Volume : 6, Issue : 3, Year : 2019

Article Page : 282-287

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Introduction: The aim of induction is to achieve successful vaginal delivery where continuation of
pregnancy is not desirable. Unfavourable cervix is one of the main causes of failed induction. Introduction
of prostaglandins has revolutionised the scenario of cervical ripening. More than one dose of Prosta glandin
E2 (PGE2) gel may be necessary to facilitate cervical ripening and increase the chances of vaginal delivery.
Materials and Methods: This retrospective study was done to find the efficacy of multiple instillations
of intravaginal Prostaglandin E2 gel and to compare the maternal and fetal outcome between the single
instillation group and multiple instillation group. The women who went into labour or achieved cervical
ripening with a single instillation of Prostaglandin E2 gel forms Group A. Those who required more than
one instillation of prostaglandin E2 gel forms Group B. Both groups were compared for specific parameters.
Results: Primigravidas required multiple instillations. Postdated pregnancy was the most common
indication for Induction of Labour. 45.2% of primis had only single dose and 54.8% required multiple
doses. About two third (77.8%) of multipara required only one dose and a third of multipara needed
multiple doses. In Group A 90.7% had vaginal delivery, 9.3% had Caesarean section. Group B 95.7% had
vaginal delivery and 4.3% had Caesarean section.
Conclusion: Though PGE2 0.5mg gel is recommended to be used intracervically, it is equally effective
intravaginally. Three doses of intravaginal PGE2 can be safely used without the risk of uterine
hyperstimulation. There is no increased fetal risk with multiple instillations of intravaginal PGE2 gel.

Keywords: Prostaglandin E2, Bishops score, Induction of Labour, Hyperstimulation.

Doi : 10.18231/j.ijogr.2019.064

How to cite : Rao M V R, Fathima N, Monica G, A comparative study of single versus multiple instillations of intravaginal PGE2 gel for induction of labour. Indian J Obstet Gynecol Res 2019;6(3):282-287

Copyright © 2019 by author(s) and Indian J Obstet Gynecol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (