Indian Journal of Obstetrics and Gynecology Research (IJOGR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, more...
Author Details :
Volume : 8, Issue : 4, Year : 2021
Article Page : 585-591
Objectives: The aim of the present study was to investigate tumor characteristics, treatment, recurrence, and prognosis in both Granulosa Cell Tumor types.
Materials and Methods: A retrospective review study of 38 patients in a single institute; We identified patients with GCTs diagnosed between 2014 and 2019 in the Regional General Dr. Soetomo Hospital. Surgical outcome, pathological findings and follow-up data were analyzed. Statistical analyses were conducted using Fisher exact test and Kaplan-Meier survival curves and compared with the log-rank test.
Results: The prevalence of AGCT subtypes as the most common type occurring in 97% of cases. The median age at diagnosis among patients with AGCT is 47.5 years (range 41-59), and most women are premenopausal and multiparous. In our literature review Stage 1 disease is 76% with Overall Survival (OS) for 5years is 89.7%. FIGO stage and adjuvant therapy was not shown a positive correlation with recurrency (p >0.05). Rate of recurrence in AGCT is reported to be as high as 5.26%.
GCT is a rare low malignant tumor, majority of patients present with early-stage disease and generally have a favorable prognosis. Stage is not considered as the most important prognostic factor. The role of adjuvant chemotherapy treatment is debatable as it was not shown to reduce recurrence rates. Long-term surveillance including routine clinical follow-up and tumor markers serial evaluation is mandatory to evaluate recurrency.
Keywords: Granulosa cell tumor, Adjuvant chemotherapy, Recurrency, Prognosis.
How to cite : Santoso E, Tjokroprawiro B A, Pradnyani N N R, Characteristics of granulosa cell tumor at Dr. Soetomo general hospital from 2014 to 2019. Indian J Obstet Gynecol Res 2021;8(4):585-591
Copyright © 2021 by author(s) and Indian J Obstet Gynecol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)