Indian Journal of Obstetrics and Gynecology Research

Print ISSN: 2394-2746

Online ISSN: 2394-2754

CODEN : IJOGCS

Indian Journal of Obstetrics and Gynecology Research (IJOGR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific more...


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Original Article


Article page

310-313


Authors Details

Manisha B Sinha*, Suprava Patel, Nilaj Bagde, H P Sinha, Apoorva Joshi


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Observational study of Y chromosome microdeletion, EAA markers and non EAA markers in Chhattishgarh


Original Article

Author Details : Manisha B Sinha*, Suprava Patel, Nilaj Bagde, H P Sinha, Apoorva Joshi

Volume : 8, Issue : 3, Year : 2021

Article Page : 310-313

https://doi.org/10.18231/j.ijogr.2021.066



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Abstract

Genetic factors contribute to 15% of all causes of male infertility. Y chromosome microdeletion is the second most common genetic cause of male infertility. Screening is important for Yq microdeletion as the defect can be transferred to offspring. Aim of our study is to detect the frequency of Y chromosome microdeletion in idiopathic infertile men using both EAA and non EAA markers in central region of India. Forty men from infertility clinic, seeking treatment of infertility were recruited in the study as cases. Thirty normal fertile men of same origin were recruited as controls. Semen analysis was done and cytogenetic normal infertile men were included in the study. Simplex and multiplex PCR methods were used to detect Yq microdeletions. Frequency of deletion was 11/40 (27.5%). Single deletion of AZF a,b,c were 12.5%, 7.5%, 2.5% respectively. Double deletions of AZF a+c and b+c were 2.5% each. Two subjects showed deletion for more than one loci. Overall frequency of deletion depends on sample size, no of markers used, inclusion criteria of subjects and geographic location. So, the screening is important for Yq microdeletion as the defect may be inherited to offspring.


Keywords: Non obstructive azoospermia, Oligozoospermia, Y chromosome microdeletion, Male infertility.


How to cite : Sinha M B, Patel S, Bagde N, Sinha H P, Joshi A, Observational study of Y chromosome microdeletion, EAA markers and non EAA markers in Chhattishgarh. Indian J Obstet Gynecol Res 2021;8(3):310-313

Copyright © 2021 by author(s) and Indian J Obstet Gynecol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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