Indian Journal of Obstetrics and Gynecology Research (IJOGR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific more...
Author Details :
Volume : 8, Issue : 1, Year : 2021
Article Page : 53-56
Background: Normal maternal thyroid function is essential for fetal growth and neurocognitive development. Intra uterine growth restriction (IUGR) is a complex condition arising from maternal, placental, or fetal mechanisms and any imbalance in thyroid function may lead to undesirable results for
both mother and fetus.
Aims and Objective: The aim of this study was to co-relate the level of thyroid stimulating hormone (TSH) in clinically diagnosed cases of intra uterine growth restriction.
Materials and Methods: A prospective study was conducted in a tertiary care hospital for a period of one year in which one hundred and twenty consecutive clinically suspected cases of singleton IUGR pregnancies at 34-40 weeks of gestation were enrolled. The reference level of TSH during the third trimester was taken as 0.3 to 3.0 mIU/ L. The TSH levels were recorded and a descriptive analysis of the data was performed.
Results: Among the 120 clinically diagnosed cases of IUGR only three antenatal mothers from rural background had TSH levels below 0.3 mIU/L. All three were vegetarians. In these, hypothyroid antenatal mothers, the delivery outcomes were; one was born dead while the other two babies were born alive and required caesarean section. However, the two born alive had a very low birth weight; less than 1.5 kgs and both needed admission to neonatal intensive care unit.
Conclusion: Since the causation of IUGR is multifactorial, the role of TSH alone may not be accurate to be used as biomarker for prediction of IUGR.
Keywords: Biomarker, Thyroid stimulating hormone, Intrauterine growth restriction.
How to cite : Ganju S , Predictive value of thyroid stimulating hormone as a biomarker in intrauterine growth restriction. Indian J Obstet Gynecol Res 2021;8(1):53-56
Copyright © 2021 by author(s) and Indian J Obstet Gynecol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)